{"id":1358,"date":"2020-08-06T22:28:17","date_gmt":"2020-08-06T22:28:17","guid":{"rendered":"https:\/\/meddists.com\/learn\/pre-clinical\/medical-genetics\/theory-questions-and-answers\/theory-questions-and-answers-i\/"},"modified":"2020-12-25T04:54:44","modified_gmt":"2020-12-25T02:54:44","slug":"theory-questions-and-answers-i","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/pre-clinical\/medical-genetics\/theory-questions-and-answers\/theory-questions-and-answers-i\/","title":{"rendered":"Theory Questions and Answers I"},"content":{"rendered":"\n

Questions<\/h4>\n<\/span>\n\n\n

Scroll down for answers!<\/em><\/p>\n\n\n\n

  1. What is the difference between somatic rearrangement and splicing? <\/li>
  2. The fusion of the centromere of 2 acrocentric chromosomes is called?<\/li>
  3. List the purines and pyrimidines. <\/li>
  4. Can a person with 46, XX differentiate into a phenotypically normal and healthy male? If yes, explain. <\/li>
  5. Briefly describe the structure and significance of the nucleosome. <\/li>
  6. A couple has a child with Down syndrome, who has a  21q21q translocation inherited from the mother. Can prenatal diagnosis be helpful in the next pregnancy? Explain. <\/li>
  7. What does it mean that the genetic code is degenerate?<\/li>
  8. Explain uniparental disomy and how it happens.<\/li>
  9. Explain the Cholinesterase polymorphism and its importance in postoperative breathing difficulties.<\/li><\/ol>\n\n\n\n
    \n\n\n<\/span>\n

    Answers<\/h4>\n<\/span>\n\n\n
    1. Somatic rearrangement is when the original DNA is rearranged. It is used in the development of T cells by the production of mature genes. In splicing, mature mRNA is made but unlike somatic rearrangement, the DNA is unchanged.<\/li>
    2. Robertsonian translocation<\/li>
    3. Purines: Adenine and Guanine\u00a0 \u00a0Pyrimidines: Cytosine, Thymine(only in DNA), and Uracil(only in RNA).<\/li>
    4. Yes, this is possible. Because the SRY gene might have been translocated to the X chromosome or an autosome.\u00a0<\/li>
    5. The nucleosome consists of DNA wrapped around the histone octamer(2 molecules of H2A, H2B, H3, and H4) plus the H1 histone that binds to DNA at the edge of the nucleosome. it acts as a peg to keep the nucleosome together. It is important because the nucleosome helps to keep genes compact and prevents transcription of certain genes when they are not needed.<\/li>
    6. Prenatal counseling is not helpful because the child can have either Down syndrome or monosomy 21(which is not compatible with life). The couple should be advised on other alternatives for having children.<\/li>
    7. It means that one or more codons can code for the same amino acid<\/li>
    8. Uniparental Disomy is when a person has 2 chromosomes from the same parent. It results from meiotic non-disjunction\u00a0<\/li>
    9. Suxamethonium\/Succinylcholine is used as a muscle relaxant for intubation anesthesia. It stops breathing and it is hydrolyzed by the butyrylcholinesterase enzyme. This inhibition lasts for 1-3 minutes, and after this time, spontaneous breathing resumes. In persons with a mutation in this enzyme, the enzyme has a poor affinity for the drug, and the muscle relaxant is not broken down quickly enough. Such patients develop prolonged apnea due to the inhibition of respiratory muscles. In such patients, longer artificial respiration with a tracheal tube is needed. This mutation is autosomal recessive. <\/li><\/ol>\n<\/span>

      Questions<\/h4>

      Answers<\/h4><\/div>","protected":false},"excerpt":{"rendered":"

      Questions Scroll down for answers! What is the difference between somatic rearrangement and splicing?  The fusion of the centromere of 2 acrocentric chromosomes is called? List the purines and pyrimidines.  Can a person with 46, XX differentiate into a phenotypically normal and healthy male? If yes, explain.  Briefly describe the structure and significance of the […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":1357,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1358","page","type-page","status-publish","hentry"],"yoast_head":"\nTheory Questions and Answers I – Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/pre-clinical\/medical-genetics\/theory-questions-and-answers\/theory-questions-and-answers-i\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" 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