{"id":10047,"date":"2022-01-13T21:01:42","date_gmt":"2022-01-13T19:01:42","guid":{"rendered":"https:\/\/meddists.com\/learn\/clinical\/internal-medicine\/hematology\/blood-products-and-transfusion\/"},"modified":"2022-01-14T19:02:14","modified_gmt":"2022-01-14T17:02:14","slug":"blood-products-and-transfusion","status":"publish","type":"page","link":"https:\/\/meddists.com\/learn\/clinical\/internal-medicine\/hematology\/blood-products-and-transfusion\/","title":{"rendered":"Blood products and transfusion"},"content":{"rendered":"\n

Blood products<\/h3>\n<\/span>\n\n\n
  • Whole blood<\/strong>
    • Whole blood is rarely used in the Western world, as blood components are generally more efficient and are equally effective.<\/li><\/ul><\/li>
    • RBCs<\/strong>
      • Packed RBCs <\/strong>are given to severely anemic patients (<7gr\/dL Hgb) and patients with severe bleeding (>15% TBV loss).<\/li>
      • Each unit increases Hgb by about 1g\/dL and Htc by 3%.<\/li><\/ul>
        • Washed pRBCs<\/strong> has most of the plasma proteins and leukocytes removed. Used in patients with a history of hypersensitivity reactions to plasma proteins.<\/li>
        • Leukocyte reduced pRBC<\/strong> is used in patients with a history of nonhemolytic febrile transfusion reactions<\/strong>, and to reduce the risk of transmission of CMV.<\/li><\/ul><\/li>
        • Platelet concentrations<\/strong>
          • Given to patients with severe throbocytopenia (<10G\/L), platelet dysfunction, and before major surgeries.<\/li>
          • Contraindicated in ITP and TTP.<\/li><\/ul><\/li>
          • Fresh frozen plasma<\/strong>
            • Clotting factors without platelets, used for factor deficiencies, DIC, and warfarin reversal (when prothrombin complex concentrate is unavailable).<\/li><\/ul><\/li>
            • Cryoprecipitate<\/strong>
              • Concentrated from fresh frozen plasma (10% of the volume). <\/li>
              • Contains mostly FVIII, FXIIII, and vWF.<\/li>
              • Used in factor deficiencies, TTP, vWF disease, hemophilia, surgeries, HELLP syndrome.<\/li><\/ul><\/li>
              • White blood cells<\/strong>
                • Used in neutropenia. Largely replaced by G-CSF and antibiotics.<\/li><\/ul><\/li>
                • Irradiated blood products<\/strong>
                  • Used for the reduction of risk for graft-vs-host disease in immunocompromised patients.<\/li>
                  • Deals damage to lymphocytes.<\/li><\/ul><\/li><\/ul>\n\n\n<\/span>\n

                    Transfusion<\/h4>\n<\/span>\n\n\n
                    • Check the patient’s details.<\/li>
                    • A sample of the patient’s blood is taken, and examined together with the donor blood using a blood typing kit.<\/li>
                    • The blood should be held at room temperature for 15-20 minutes prior to the transfusion.<\/li>
                    • 18-gauge or larger needles are required for the prevention of RBC damage.<\/li>
                    • Each unit of blood should be completed in less than 4 hour.<\/li>
                    • Massive blood transfusion<\/strong> is the transfusion of 10 or more blood components within 24 hours.<\/li><\/ul>\n<\/span>

                      Blood products<\/h3>

                      Transfusion<\/h4><\/div>","protected":false},"excerpt":{"rendered":"

                      Blood products Whole blood Whole blood is rarely used in the Western world, as blood components are generally more efficient and are equally effective. RBCs Packed RBCs are given to severely anemic patients (<7gr\/dL Hgb) and patients with severe bleeding (>15% TBV loss). Each unit increases Hgb by about 1g\/dL and Htc by 3%. Washed […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":4472,"menu_order":9,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-10047","page","type-page","status-publish","hentry"],"yoast_head":"\nBlood products and transfusion – Meddists<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/meddists.com\/learn\/clinical\/internal-medicine\/hematology\/blood-products-and-transfusion\/\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" 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